Relation of Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q Waves With Long-Term Cardiovascular Death in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease.
Identifieur interne : 001827 ( Main/Exploration ); précédent : 001826; suivant : 001828Relation of Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q Waves With Long-Term Cardiovascular Death in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease.
Auteurs : Michael Domanski [Canada] ; Michael E. Farkouh [Canada] ; Victor Zak [États-Unis] ; John French [Australie] ; John H. Alexander [États-Unis] ; Andrzej Bochenek [Pologne] ; Martial Hamon [France] ; Kenneth Mahaffey [États-Unis] ; John Puskas [France] ; Peter Smith [Géorgie (pays)] ; Peter Shrader [États-Unis] ; Valentin Fuster [Espagne]Source :
- The American journal of cardiology [ 1879-1913 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cause de décès (tendances), Coronarographie, Diabète (mortalité), Diabète (sang), Europe (épidémiologie), Femelle, Humains, MB Creatine kinase (sang), Maladie des artères coronaires (), Maladie des artères coronaires (diagnostic), Maladie des artères coronaires (enzymologie), Maladie des artères coronaires (mortalité), Marqueurs biologiques (sang), Mâle, Nouvelle-Galles du Sud (épidémiologie), Ontario (épidémiologie), Pontage aortocoronarien, Pronostic, Période postopératoire, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie (tendances), Vaisseaux coronaires (), Vaisseaux coronaires (imagerie diagnostique), Électrocardiographie, États-Unis d'Amérique (épidémiologie).
- MESH :
- diagnostic : Maladie des artères coronaires.
- enzymologie : Maladie des artères coronaires.
- imagerie diagnostique : Vaisseaux coronaires.
- mortalité : Diabète, Maladie des artères coronaires.
- sang : Diabète, MB Creatine kinase, Marqueurs biologiques.
- tendances : Cause de décès, Taux de survie.
- épidémiologie : Europe, Nouvelle-Galles du Sud, Ontario, États-Unis d'Amérique.
- Adulte, Adulte d'âge moyen, Coronarographie, Femelle, Humains, Maladie des artères coronaires, Mâle, Pontage aortocoronarien, Pronostic, Période postopératoire, Sujet âgé, Sujet âgé de 80 ans ou plus, Vaisseaux coronaires, Électrocardiographie.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Biomarkers (blood), Cause of Death (trends), Coronary Angiography, Coronary Artery Bypass, Coronary Artery Disease (diagnosis), Coronary Artery Disease (enzymology), Coronary Artery Disease (mortality), Coronary Artery Disease (surgery), Coronary Vessels (diagnostic imaging), Coronary Vessels (surgery), Creatine Kinase, MB Form (blood), Diabetes Mellitus (blood), Diabetes Mellitus (mortality), Electrocardiography, Europe (epidemiology), Female, Humans, Male, Middle Aged, New South Wales (epidemiology), Ontario (epidemiology), Postoperative Period, Prognosis, Survival Rate (trends), United States (epidemiology).
- MESH :
- chemical , blood : Biomarkers, Creatine Kinase, MB Form.
- blood : Diabetes Mellitus.
- diagnosis : Coronary Artery Disease.
- diagnostic imaging : Coronary Vessels.
- enzymology : Coronary Artery Disease.
- epidemiology : Europe, New South Wales, Ontario, United States.
- mortality : Coronary Artery Disease, Diabetes Mellitus.
- surgery : Coronary Artery Disease, Coronary Vessels.
- trends : Cause of Death, Survival Rate.
- Adult, Aged, Aged, 80 and over, Coronary Angiography, Coronary Artery Bypass, Electrocardiography, Female, Humans, Male, Middle Aged, Postoperative Period, Prognosis.
Abstract
Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large population of patients with diabetes mellitus. In this study, we examine the association of periprocedural CK-MB elevations and new Q waves with CVD in the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial. Cox proportional hazards regression was used to assess the relation of CK-MB elevations and new Q waves in the first 24 hours after procedure and their relation to CVD; logistic regression was used to assess odds ratios of these variables. Hazard ratios, 95% confidence intervals, and p values associated with Wald chi-square test are reported. CK-MB elevation in first 24 hours after procedure was independently associated with CVD. CVD hazard increased by 6% (p <0.001) with each multiple of CK-MB above the upper reference limit (URL); odds of new post-CABG Q waves increased by a factor of 1.08 (p <0.001); at 7× CK-MB URL, HR was >2. CK-MB URL multiples of 7, 12, and 15 were associated with new Q-wave odds ratios of 9, 16, and 27 times, respectively (p ≤0.001, C-statistic >0.70). New Q waves were independently associated with survival in the multivariate model only when CK-MB was excluded (p = 0.01). In conclusion, independent associations included (1) CVD and early post-CABG CK-MB elevation; (2) new Q waves with early post-CABG CK-MB elevation; (3) CVD with new Q waves only when CK-MB elevation is excluded from analysis.
DOI: 10.1016/j.amjcard.2016.08.041
PubMed: 27816118
Affiliations:
- Australie, Canada, Espagne, France, Géorgie (pays), Pologne, États-Unis
- Basse-Normandie, Caroline du Nord, Communauté de Madrid, Massachusetts, Nouvelle-Galles du Sud, Ontario, Région Normandie
- Caen, Madrid, Sydney, Toronto
- Université de Toronto
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Le document en format XML
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Electronic address: michael.domanski@uhn.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Farkouh, Michael E" sort="Farkouh, Michael E" uniqKey="Farkouh M" first="Michael E" last="Farkouh">Michael E. Farkouh</name><affiliation wicri:level="4"><nlm:affiliation>Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Zak, Victor" sort="Zak, Victor" uniqKey="Zak V" first="Victor" last="Zak">Victor Zak</name><affiliation wicri:level="2"><nlm:affiliation>The New England Research Institute, Watertown, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The New England Research Institute, Watertown</wicri:cityArea></affiliation></author><author><name sortKey="French, John" sort="French, John" uniqKey="French J" first="John" last="French">John French</name><affiliation wicri:level="3"><nlm:affiliation>Liverpool Hospital, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Liverpool Hospital, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Alexander, John H" sort="Alexander, John H" uniqKey="Alexander J" first="John H" last="Alexander">John H. Alexander</name><affiliation wicri:level="2"><nlm:affiliation>Duke Clinical Research Institute, Duke Medicine, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke Clinical Research Institute, Duke Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Bochenek, Andrzej" sort="Bochenek, Andrzej" uniqKey="Bochenek A" first="Andrzej" last="Bochenek">Andrzej Bochenek</name><affiliation wicri:level="1"><nlm:affiliation>Medical University of Silesia, Katowice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Hamon, Martial" sort="Hamon, Martial" uniqKey="Hamon M" first="Martial" last="Hamon">Martial Hamon</name><affiliation wicri:level="3"><nlm:affiliation>CHU Caen, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Caen, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Mahaffey, Kenneth" sort="Mahaffey, Kenneth" uniqKey="Mahaffey K" first="Kenneth" last="Mahaffey">Kenneth Mahaffey</name><affiliation wicri:level="2"><nlm:affiliation>Duke Clinical Research Institute, Duke Medicine, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke Clinical Research Institute, Duke Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Puskas, John" sort="Puskas, John" uniqKey="Puskas J" first="John" last="Puskas">John Puskas</name><affiliation wicri:level="3"><nlm:affiliation>CHU Caen, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Caen, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Smith, Peter" sort="Smith, Peter" uniqKey="Smith P" first="Peter" last="Smith">Peter Smith</name><affiliation wicri:level="1"><nlm:affiliation>Emory University Hospital Midtown, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Emory University Hospital Midtown, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Shrader, Peter" sort="Shrader, Peter" uniqKey="Shrader P" first="Peter" last="Shrader">Peter Shrader</name><affiliation wicri:level="2"><nlm:affiliation>The New England Research Institute, Watertown, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The New England Research Institute, Watertown</wicri:cityArea></affiliation></author><author><name sortKey="Fuster, Valentin" sort="Fuster, Valentin" uniqKey="Fuster V" first="Valentin" last="Fuster">Valentin Fuster</name><affiliation wicri:level="3"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, New York, NY; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, New York, NY; Centro Nacional de Investigaciones Cardiovasculares, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">The American journal of cardiology</title><idno type="eISSN">1879-1913</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Biomarkers (blood)</term><term>Cause of Death (trends)</term><term>Coronary Angiography</term><term>Coronary Artery Bypass</term><term>Coronary Artery Disease (diagnosis)</term><term>Coronary Artery Disease (enzymology)</term><term>Coronary Artery Disease (mortality)</term><term>Coronary Artery Disease (surgery)</term><term>Coronary Vessels (diagnostic imaging)</term><term>Coronary Vessels (surgery)</term><term>Creatine Kinase, MB Form (blood)</term><term>Diabetes Mellitus (blood)</term><term>Diabetes Mellitus (mortality)</term><term>Electrocardiography</term><term>Europe (epidemiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>New South Wales (epidemiology)</term><term>Ontario (epidemiology)</term><term>Postoperative Period</term><term>Prognosis</term><term>Survival Rate (trends)</term><term>United States (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cause de décès (tendances)</term><term>Coronarographie</term><term>Diabète (mortalité)</term><term>Diabète (sang)</term><term>Europe (épidémiologie)</term><term>Femelle</term><term>Humains</term><term>MB Creatine kinase (sang)</term><term>Maladie des artères coronaires ()</term><term>Maladie des artères coronaires (diagnostic)</term><term>Maladie des artères coronaires (enzymologie)</term><term>Maladie des artères coronaires (mortalité)</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Nouvelle-Galles du Sud (épidémiologie)</term><term>Ontario (épidémiologie)</term><term>Pontage aortocoronarien</term><term>Pronostic</term><term>Période postopératoire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie (tendances)</term><term>Vaisseaux coronaires ()</term><term>Vaisseaux coronaires (imagerie diagnostique)</term><term>Électrocardiographie</term><term>États-Unis d'Amérique (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Creatine Kinase, MB Form</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Diabetes Mellitus</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronary Artery Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie des artères coronaires</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Coronary Vessels</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Maladie des artères coronaires</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Coronary Artery Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Europe</term><term>New South Wales</term><term>Ontario</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Vaisseaux coronaires</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronary Artery Disease</term><term>Diabetes Mellitus</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Diabète</term><term>Maladie des artères coronaires</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Diabète</term><term>MB Creatine kinase</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Coronary Artery Disease</term><term>Coronary Vessels</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Cause de décès</term><term>Taux de survie</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Cause of Death</term><term>Survival Rate</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term><term>Nouvelle-Galles du Sud</term><term>Ontario</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Coronary Angiography</term><term>Coronary Artery Bypass</term><term>Electrocardiography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Postoperative Period</term><term>Prognosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronarographie</term><term>Femelle</term><term>Humains</term><term>Maladie des artères coronaires</term><term>Mâle</term><term>Pontage aortocoronarien</term><term>Pronostic</term><term>Période postopératoire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Vaisseaux coronaires</term><term>Électrocardiographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large population of patients with diabetes mellitus. In this study, we examine the association of periprocedural CK-MB elevations and new Q waves with CVD in the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial. Cox proportional hazards regression was used to assess the relation of CK-MB elevations and new Q waves in the first 24 hours after procedure and their relation to CVD; logistic regression was used to assess odds ratios of these variables. Hazard ratios, 95% confidence intervals, and p values associated with Wald chi-square test are reported. CK-MB elevation in first 24 hours after procedure was independently associated with CVD. CVD hazard increased by 6% (p <0.001) with each multiple of CK-MB above the upper reference limit (URL); odds of new post-CABG Q waves increased by a factor of 1.08 (p <0.001); at 7× CK-MB URL, HR was >2. CK-MB URL multiples of 7, 12, and 15 were associated with new Q-wave odds ratios of 9, 16, and 27 times, respectively (p ≤0.001, C-statistic >0.70). New Q waves were independently associated with survival in the multivariate model only when CK-MB was excluded (p = 0.01). In conclusion, independent associations included (1) CVD and early post-CABG CK-MB elevation; (2) new Q waves with early post-CABG CK-MB elevation; (3) CVD with new Q waves only when CK-MB elevation is excluded from analysis.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Géorgie (pays)</li><li>Pologne</li><li>États-Unis</li></country><region><li>Basse-Normandie</li><li>Caroline du Nord</li><li>Communauté de Madrid</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Région Normandie</li></region><settlement><li>Caen</li><li>Madrid</li><li>Sydney</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Domanski, Michael" sort="Domanski, Michael" uniqKey="Domanski M" first="Michael" last="Domanski">Michael Domanski</name></region><name sortKey="Farkouh, Michael E" sort="Farkouh, Michael E" uniqKey="Farkouh M" first="Michael E" last="Farkouh">Michael E. Farkouh</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Zak, Victor" sort="Zak, Victor" uniqKey="Zak V" first="Victor" last="Zak">Victor Zak</name></region><name sortKey="Alexander, John H" sort="Alexander, John H" uniqKey="Alexander J" first="John H" last="Alexander">John H. Alexander</name><name sortKey="Mahaffey, Kenneth" sort="Mahaffey, Kenneth" uniqKey="Mahaffey K" first="Kenneth" last="Mahaffey">Kenneth Mahaffey</name><name sortKey="Shrader, Peter" sort="Shrader, Peter" uniqKey="Shrader P" first="Peter" last="Shrader">Peter Shrader</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="French, John" sort="French, John" uniqKey="French J" first="John" last="French">John French</name></region></country><country name="Pologne"><noRegion><name sortKey="Bochenek, Andrzej" sort="Bochenek, Andrzej" uniqKey="Bochenek A" first="Andrzej" last="Bochenek">Andrzej Bochenek</name></noRegion></country><country name="France"><region name="Région Normandie"><name sortKey="Hamon, Martial" sort="Hamon, Martial" uniqKey="Hamon M" first="Martial" last="Hamon">Martial Hamon</name></region><name sortKey="Puskas, John" sort="Puskas, John" uniqKey="Puskas J" first="John" last="Puskas">John Puskas</name></country><country name="Géorgie (pays)"><noRegion><name sortKey="Smith, Peter" sort="Smith, Peter" uniqKey="Smith P" first="Peter" last="Smith">Peter Smith</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Fuster, Valentin" sort="Fuster, Valentin" uniqKey="Fuster V" first="Valentin" last="Fuster">Valentin Fuster</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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